Description

1-Cyclopropyl-3-(4-Fluorophenyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group, enabling critical carbon-carbon bond formation in modern synthetic chemistry. This compound is essential for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the global life sciences industry.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing biaryl and heterobiaryl structures central to many drug molecules.
• Pharmaceutical Intermediate: Used in the research, development, and scale-up synthesis of potential drug candidates, especially in oncology, CNS, and anti-inflammatory fields.
• Medicinal Chemistry & Drug Discovery: Enables rapid analoging and structure-activity relationship (SAR) studies due to its versatile reactivity.
• Process Chemistry Development: Employed in route scouting and optimization for the efficient, scalable production of target APIs.
• Chemical Biology & Probe Development: Utilized to create molecular probes for studying biological pathways and target validation.
• Material Science Research: Potential building block for creating organic electronic materials or metal-organic frameworks (MOFs) with specific properties.

Basic Information

Product Name	1-Cyclopropyl-3-(4-Fluorophenyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1286230-76-9
Molecular Formula	C₁₈H₂₂BFN₂O₂
Molecular Weight	328.19 g/mol
Synonyms	1-Cyclopropyl-3-(4-fluorophenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-cyclopropyl-3-(4-fluorophenyl)-1H-pyrazole; 1-Cyclopropyl-3-(4-fluorophenyl)-1H-pyrazole-4-boronic acid pinacol ester; 3-(4-Fluorophenyl)-1-cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1286230-76-9; Pyrazole boronic ester intermediate; Fluorophenyl cyclopropyl pyrazole boronate
EINECS	Contact for details

Quality Control

Our production of 1-Cyclopropyl-3-(4-Fluorophenyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.