Description

(1R)-6,6'-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Diol CAS NO 1286189-16-9 is a high-value, chiral spirobiindane derivative characterized by its unique three-dimensional structure and electron-withdrawing trifluoromethyl groups. This compound is a critical ligand precursor in asymmetric catalysis, enabling the synthesis of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel catalysts with superior selectivity and activity.

Application

• Asymmetric Catalysis: Serves as a privileged scaffold for constructing chiral phosphine, phosphoramidite, and N-heterocyclic carbene (NHC) ligands used in C-C and C-X bond-forming reactions.
• Pharmaceutical Intermediate Synthesis: Key building block for developing novel active pharmaceutical ingredients (APIs) requiring high enantiomeric purity, particularly in oncology and CNS drug discovery.
• Agrochemical Research: Used in the development of enantioselective herbicides, fungicides, and plant growth regulators.
• Material Science: Precursor for chiral dopants in liquid crystal displays (LCDs) and for creating metal-organic frameworks (MOFs) with specific chiral recognition properties.
• Academic & Industrial R&D: Essential tool compound for methodological studies in organic synthesis and catalysis research.

Basic Information

Product Name	(1R)-6,6'-Bis[3,5-Bis(Trifluoromethyl)Phenyl]-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1286189-16-9
Molecular Formula	C43H24F12O2
Molecular Weight	800.64 g/mol
Synonyms	(R)-6,6'-Bis[3,5-Bis(trifluoromethyl)phenyl]-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol; (1R)-Spirobiindane-7,7'-diol Derivative; (R)-DTB-SPINOL; (R)-3,3'-Bis(3,5-bis(trifluoromethyl)phenyl)-1,1'-spirobiindane-7,7'-diol; Chiral Spiro Diol Ligand Precursor; SPINOL-Based Trifluoromethylated Ligand; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, 1H/19F NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profile is provided with every shipment, supporting cGMP and ISO 9001 compliant workflows for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere (argon or nitrogen) after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.