Description

4-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyrazinyl]Morpholine is a high-purity, advanced pharmaceutical intermediate and building block featuring a morpholine-substituted pyrazine core with a pinacol boronate ester functional group. This compound matters as a critical reagent in modern synthetic chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex heterocyclic scaffolds. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional molecules. CAS No. 1283180-64-2.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds to attach complex aryl and heteroaryl groups to the pyrazine core.
• Agrochemical Research: Used in the discovery and synthesis of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic semiconductors.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable tool for synthetic methodology development and exploring new chemical spaces in academic and CRO laboratories.

Basic Information

Product Name	4-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyrazinyl]Morpholine
CAS No.	1283180-64-2
Molecular Formula	C15H22BN3O3
Molecular Weight	303.17 g/mol
Synonyms	4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-2-yl)morpholine; 2-Morpholino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; 4-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazin-2-yl]morpholine; 1283180-64-2; 4-(5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrazinyl)morpholine; Boronic acid, B-[6-(4-morpholinyl)-3-pyrazinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 4-[5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyrazinyl]Morpholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.