Description

2-Cyclopropyl-Thiazole-4-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic scaffolds.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Cross-Coupling Reactions: An essential reagent for Suzuki-Miyaura cross-coupling, enabling carbon-carbon bond formation between aryl/heteroaryl halides and boronic esters.
• Chemical Library Synthesis: Employed in combinatorial chemistry and high-throughput screening to generate diverse compound libraries for biological evaluation.
• Academic & Contract Research: A valuable tool for synthetic methodology development and complex molecule construction in academic and CRO laboratories.

Basic Information

Product Name	2-Cyclopropyl-Thiazole-4-Boronic Acid Pinacol Ester
CAS No.	1283179-55-4
Molecular Formula	C₁₂H₁₈BNO₂S
Molecular Weight	251.15 g/mol
Synonyms	2-Cyclopropyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopropylthiazole; 2-Cyclopropylthiazole-4-boronic acid pinacol ester; (2-Cyclopropylthiazol-4-yl)boronic acid pinacol ester; 2-Cyclopropyl-4-(pinacolatoboryl)thiazole; Thiazole-4-boronic acid, 2-cyclopropyl-, pinacol ester; B-(2-Cyclopropyl-4-thiazolyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-Thiazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.