Description

2-Chloro-4-Dimethylamino-Pyridine-3-Carbaldehyde is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both an aldehyde and a chloro-dimethylamino substitution pattern, makes it an invaluable precursor for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the pyridine core is a common bioactive scaffold.
• Ligand and Catalyst Development: Serves as a precursor for creating sophisticated chelating ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functional organic materials, such as dyes, pigments, and molecular sensors, due to its electron-donating and accepting properties.
• Chemical Biology Probes: Utilized to develop tool compounds and fluorescent probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	2-Chloro-4-Dimethylamino-Pyridine-3-Carbaldehyde
CAS No.	1282606-18-1
Molecular Formula	C8H9ClN2O
Molecular Weight	184.62 g/mol
Synonyms	2-Chloro-4-(dimethylamino)pyridine-3-carboxaldehyde; 3-Formyl-2-chloro-4-(dimethylamino)pyridine; 2-Chloro-4-(N,N-dimethylamino)nicotinaldehyde; 4-(Dimethylamino)-2-chloropyridine-3-carbaldehyde; 1282606-18-1; 2-Chloro-4-dimethylaminonicotinaldehyde
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Dimethylamino-Pyridine-3-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GMP and ISO-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.