Description

1-Isopropyl-1H-Pyrazole-5-Boronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl scaffolds central to active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyrazole-based structures.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its functional handle for polymerization or derivatization.
• Chemical Biology & Medicinal Chemistry: Utilized as a versatile building block for creating compound libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Catalyst & Ligand Development: Serves as a precursor for synthesizing novel N-heterocyclic carbene (NHC) ligands or other catalytic complexes.
• Academic & Contract Research: An essential tool for methodology development in organic synthesis laboratories at universities and CROs (Contract Research Organizations).

Basic Information

Item	Details
Product Name	1-Isopropyl-1H-Pyrazole-5-Boronic Acid, Pinacol Ester
CAS No.	1282518-60-8
Molecular Formula	C12H21BN2O2
Molecular Weight	236.12 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isopropyl-1H-pyrazole; 1-Isopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole-5-boronic acid, 1-(1-methylethyl)-, pinacol ester; 1-Isopropyl-1H-pyrazol-5-ylboronic acid pinacol ester; 1-Isopropyl-5-(pinacolboron)-1H-pyrazole; Pyrazole boronic ester, isopropyl-substituted; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 1-Isopropyl-1H-Pyrazole-5-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every lot and provided upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.