Description

2-Bromo-4-Butylcarbonyl-1-Chlorobenzene is a high-purity halogenated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromo and chloro substituents adjacent to a butylcarbonyl group, makes it a versatile and valuable intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and fungicides, leveraging its reactive halogen sites for further functionalization.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional handles.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to create complex, diversely substituted aromatic systems.
• Laboratory Reagent: Used as a standardized reagent in academic and industrial R&D settings for method development and scale-up studies.

Basic Information

Product Name	2-Bromo-4-Butylcarbonyl-1-Chlorobenzene
CAS No.	1280786-92-6
Molecular Formula	C11H12BrClO
Molecular Weight	275.57 g/mol
Synonyms	1-Chloro-2-bromo-4-butyrylbenzene; 4'-Chloro-3'-bromobutyrophenone; 2-Bromo-4-butyryl-1-chlorobenzene; 1-Chloro-2-bromo-4-(1-oxobutyl)benzene; Butyrophenone, 4'-chloro-3'-bromo-; 3'-Bromo-4'-chlorobutyrophenone; (3-Bromo-4-chlorophenyl) propyl ketone
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Each batch of 2-Bromo-4-Butylcarbonyl-1-Chlorobenzene is analyzed using advanced techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality management system is designed to support cGMP and ISO standards for traceability and reliability, meeting the exacting requirements of global R&D and scale-up operations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maximize stability. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.