Description

Dichloro[(4R,5R)-(-)-4,5-Bis(Diphenylphosphinomethyl)-2,2-Dimethyl-1,3-Dioxolane][(R)-(+)-2-(α-Methylmethanamine)-1H-Benzimidazole]Ruthenium(II) is a highly specialized, chiral ruthenium complex designed for advanced asymmetric catalysis. This compound matters because it serves as a precise and efficient catalyst for critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the synthesis of enantiomerically pure intermediates. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams focused on developing novel active pharmaceutical ingredients (APIs) and high-value chiral compounds.

Application

• Asymmetric Hydrogenation: A key catalyst for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Enables the production of enantiomerically pure building blocks for APIs in oncology, CNS, and cardiovascular therapies.
• Asymmetric Transfer Hydrogenation: Useful for reactions where molecular hydrogen is not the preferred hydrogen source.
• Methodology Development in Organic Synthesis: Employed in academic and industrial research to develop new catalytic asymmetric transformations.
• Fine Chemical and Agrochemical Production: For the synthesis of chiral ligands, fragrances, and advanced crop protection agents.
• Catalyst Screening Libraries: Serves as a high-value component in catalyst libraries for high-throughput screening in process chemistry.

Basic Information

Product Name	Dichloro[(4R,5R)-(-)-4,5-Bis(Diphenylphosphinomethyl)-2,2-Dimethyl-1,3-Dioxolane][(R)-(+)-2-(α-Methylmethanamine)-1H-Benzimidazole]Ruthenium(II)
CAS No.	1280732-29-7
Molecular Formula	C48H48Cl2N2O2P2Ru
Molecular Weight	948.82 g/mol
Synonyms	Ru-DIOP-BINAP Hybrid Catalyst; (R,R)-DIOP-(R)-BINAM Ru(II) Complex; Dichloro[(4R,5R)-(-)-DIOP][(R)-(+)-BINAM]Ruthenium(II); Asymmetric Ruthenium DIOP BINAM Catalyst; Ruthenium(II) dichloride with (4R,5R)-(-)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane and (R)-(+)-1,1'-Bi-2-naphthylamine; [RuCl2((R,R)-DIOP)((R)-BINAM)]; CAS 1280732-29-7
EINECS	Contact for details

Quality Control

Every batch of our chiral ruthenium catalysts is produced and controlled under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and elemental analysis to verify chemical identity, enantiomeric purity, and catalytic activity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral assay, and residual solvent levels is provided with each shipment to ensure traceability and compliance with your R&D and cGMP documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., argon or nitrogen) to maintain stability and catalytic activity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Elemental Analysis (C, H, N)	Within theoretical ± 0.4%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.