Description

Dichloro[(4S,5S)-(+)-4,5-Bis(Diphenylphosphinomethyl)-2,2-Dimethyl-1,3-Dioxolane][(S)-(-)-2-(α-Methylmethanamine)-1H-Benzimidazole]Ruthenium(Ii) is a sophisticated chiral ruthenium(II) complex, specifically engineered for high-precision asymmetric catalysis. This compound matters for its exceptional ability to induce stereoselectivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the synthesis of complex, single-enantiomer molecules. It is an essential tool for researchers and process chemists in the pharmaceutical and fine chemical industries who require reliable, high-performance catalysts for developing novel active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective reduction of prochiral olefins, ketones, and imines, crucial for producing chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Enables the efficient, stereocontrolled construction of complex molecular architectures found in drug candidates for oncology, CNS disorders, and infectious diseases.
• Fine Chemical Manufacturing: Used in the production of high-value chiral building blocks, flavors, fragrances, and agrochemicals where optical purity is paramount.
• Methodology Development in Organic Chemistry: Serves as a key reagent in academic and industrial R&D for developing new catalytic asymmetric transformations.
• Process Chemistry Optimization: Employed to scale up enantioselective reactions from laboratory to pilot plant and commercial production, offering potential advantages in yield and selectivity.

Basic Information

Product Name	Dichloro[(4S,5S)-(+)-4,5-Bis(Diphenylphosphinomethyl)-2,2-Dimethyl-1,3-Dioxolane][(S)-(-)-2-(α-Methylmethanamine)-1H-Benzimidazole]Ruthenium(Ii)
CAS No.	1280730-21-3
Molecular Formula	C48H48Cl2N2O2P2Ru
Molecular Weight	932.82 g/mol
Synonyms	Ru-DIOP-Benzimidazole Complex; (S,S)-DIOP-(S)-Benzimidazole Ru(II) Dichloride; Chiral Ruthenium DIOP Catalyst; Dichloro[(4S,5S)-DIOP][(S)-2-(Aminomethyl)benzimidazole]ruthenium(II); Asymmetric Hydrogenation Catalyst Ru-1280730-21-3; Ruthenium complex with (4S,5S)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl-1,3-dioxolane and (S)-2-(Aminomethyl)-1H-benzimidazole
EINECS	Contact for details

Quality Control

Every batch of our chiral ruthenium catalyst is synthesized and handled under strict inert atmosphere conditions to preserve its catalytic activity and stereochemical integrity. We employ advanced analytical techniques including HPLC, NMR (¹H and ³¹P), and elemental analysis to verify identity, enantiomeric purity, and chemical composition. A comprehensive Certificate of Analysis (COA) detailing assay purity, chiral purity, and residual solvent levels is provided with each shipment, ensuring full traceability and compliance with your research or quality management protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain long-term stability and prevent decomposition or oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% ee
Elemental Analysis	Within theoretical ± 0.4%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.