Description

1-(Tetrahydro-2H-Pyran-2-Yl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, multi-functional heterocyclic building block that combines a pyrazole core with both a tetrahydropyran (THP) protecting group and a pinacol boronate ester. This compound matters because it serves as a critical intermediate in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecular architectures. Pharmaceutical, agrochemical, and advanced materials researchers need it for the streamlined development of new active ingredients and functional molecules, where its boronate moiety facilitates precise carbon-carbon bond formation.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating libraries of pyrazole-containing compounds via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require the incorporation of the pyrazole heterocycle for biological activity.
• Material Science: Employed in the synthesis of organic semiconductors, ligands for catalysis, and other functional organic materials where precise molecular structure is paramount.
• Chemical Synthesis: Serves as a versatile reagent in academic and industrial R&D for constructing complex molecules, leveraging its protected amine and boronic ester functionalities.
• Ligand & Catalyst Development: The pyrazole moiety can act as a coordinating ligand, making this compound useful in designing new metal-organic complexes and catalysts.

Basic Information

Product Name	1-(Tetrahydro-2H-Pyran-2-Yl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1279088-80-0
Molecular Formula	C14H23BN2O3
Molecular Weight	278.16 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-(tetrahydro-2H-pyran-2-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-THP-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1-(THP)-3-Bpin-pyrazole; Pyrazole boronic acid pinacol ester, THP-protected; 1-(Oxan-2-yl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydro-2H-Pyran-2-Yl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.