Description

6-Bromo-4-Trifluoromethyl-Indan-1-One is a high-value, multi-functional indanone derivative featuring both bromine and trifluoromethyl substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the biological activity of the trifluoromethyl group.
• Material Science Building Block: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fluorine Chemistry: Acts as a valuable source of the trifluoromethyl moiety for introducing fluorine into target molecules to enhance metabolic stability and lipophilicity.

Basic Information

Product Name	6-Bromo-4-Trifluoromethyl-Indan-1-One
CAS No.	1273655-84-7
Molecular Formula	C11H6BrF3O
Molecular Weight	291.06 g/mol
Synonyms	6-Bromo-4-(trifluoromethyl)-2,3-dihydro-1H-inden-1-one; 1H-Inden-1-one, 6-bromo-4-(trifluoromethyl)-2,3-dihydro-; 6-Bromo-4-trifluoromethylindan-1-one; 4-Trifluoromethyl-6-bromoindan-1-one; 6-Bromo-4-(trifluoromethyl)indan-1-one; 1273655-84-7; 6-Bromo-4-(trifluoromethyl)-1-indanone
EINECS	Contact for details

Quality Control

Our 6-Bromo-4-Trifluoromethyl-Indan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP standards for pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.