Description

2,2-Difluoro-1-(3-Fluorophenyl)Ethanone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique difluoroacetyl moiety adjacent to a fluorinated aromatic ring makes it a critical intermediate for introducing specific fluorine patterns into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides where fluorine atoms enhance bioavailability and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic electronic materials.
• Fluorine Chemistry Research: A valuable reagent for studying nucleophilic substitution and coupling reactions involving difluoroacetyl groups.
• Ligand and Catalyst Development: Utilized in the preparation of novel fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2,2-Difluoro-1-(3-Fluorophenyl)Ethanone
CAS No.	1271475-01-4
Molecular Formula	C8H5F3O
Molecular Weight	174.12 g/mol
Synonyms	3-Fluoro-α,α-difluoroacetophenone; 1-(3-Fluorophenyl)-2,2-difluoroethan-1-one; 2,2-Difluoro-1-(3-fluorophenyl)ethanone; 3-Fluorophenyldifluoromethyl ketone; α,α-Difluoro-3-fluoroacetophenone; (3-Fluorophenyl)difluoromethyl ketone; Difluoro(3-fluorophenyl)methanone
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-1-(3-Fluorophenyl)Ethanone is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.