Description

2,2-Difluoro-1-(3-Methoxyphenyl)Ethanone is a high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its unique difluoromethyl ketone moiety adjacent to a methoxyphenyl ring makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and fungicides, where the difluoro group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, contributing unique fluorine-based properties like chemical resistance and altered dielectric constants.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and the exploration of new fluorination reactions.
• Ligand and Catalyst Design: The ketone functionality provides a handle for creating chelating ligands or organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	2,2-Difluoro-1-(3-Methoxyphenyl)Ethanone
CAS No.	1271473-84-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	3'-Methoxy-2,2-difluoroacetophenone; 1-(3-Methoxyphenyl)-2,2-difluoroethanone; 2,2-Difluoro-1-(3-methoxyphenyl)ethan-1-one; 2,2-Difluoro-3'-methoxyacetophenone; α,α-Difluoro-3-methoxyacetophenone; 3-Methoxyphenyl difluoromethyl ketone; DFMPK (abbrev.); (3-Methoxyphenyl)(difluoro)methanone
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-1-(3-Methoxyphenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.