Description

1-(3-(Difluoromethyl)Phenyl)-2,2,2-Trifluoroethanamine is a high-value, fluorinated aromatic amine building block of significant interest in advanced organic synthesis. Its unique structure, featuring both difluoromethyl and trifluoroethylamine moieties, makes it a critical intermediate for developing novel compounds with tailored properties. This specialty chemical is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for incorporating fluorine to modulate metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in creating advanced active ingredients for crop protection products, where the fluorine atoms can enhance pesticidal activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for designing novel ligands and organocatalysts used in asymmetric synthesis and other specialized chemical transformations.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, or other advanced materials requiring specific electronic or surface properties.
• Chemical Biology Probes: Utilized to build molecular probes for studying biological systems, leveraging fluorine as a tag for NMR spectroscopy (19F-NMR).

Basic Information

Item	Details
Product Name	1-(3-(Difluoromethyl)Phenyl)-2,2,2-Trifluoroethanamine
CAS No.	1270481-94-1
Molecular Formula	C9H8F5N
Molecular Weight	225.16 g/mol
Synonyms	α,α,α-Trifluoro-3-(difluoromethyl)benzeneethanamine; 2,2,2-Trifluoro-1-[3-(difluoromethyl)phenyl]ethanamine; 1-[3-(Difluoromethyl)phenyl]-2,2,2-trifluoroethan-1-amine; 3-(Difluoromethyl)-α,α,α-trifluorophenethylamine; (3-(Difluoromethyl)phenyl)(trifluoromethyl)methanamine
EINECS	Contact for details

Quality Control

Every batch of 1-(3-(Difluoromethyl)Phenyl)-2,2,2-Trifluoroethanamine is produced and tested under a strict quality management system. We ensure high purity and batch-to-batch consistency through comprehensive analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.