Description

3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-purity, advanced pharmaceutical intermediate featuring a versatile boronic ester pinacol group. This compound is a critical building block in modern organic synthesis, enabling efficient cross-coupling reactions to construct complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key arylboronic ester reagent for constructing biaryl and heterobiaryl scaffolds prevalent in drug discovery.
• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas, including oncology and CNS disorders.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Precursor for organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Used in the development of molecular probes and sensors for biochemical research.
• Custom Synthesis & Contract Manufacturing: Serves as a specialized starting material for custom synthesis projects and scale-up processes.

Basic Information

Product Name	3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1269233-11-5
Molecular Formula	C12H17BClNO2
Molecular Weight	253.53 g/mol
Synonyms	3-Amino-5-chlorophenylboronic acid pinacol ester; (3-Amino-5-chlorophenyl)boronic acid pinacol ester; 5-Amino-3-chlorophenylboronic acid pinacol ester; 3-Chloro-5-aminophenylboronic acid pinacol ester; 3-Chloro-5-aminophenyl-Bpin; 1269233-11-5; 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles via HPLC, NMR, and other analytical techniques are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0% (Area %)
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.