Description

2-Chloro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Al)Aniline is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters because it enables efficient, precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific chloroaniline-boronic ester motifs.
• Material Science Research: Serves as a precursor for creating organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Suzuki-Miyaura Cross-Coupling: The protected boronic ester functionality provides enhanced stability and reactivity for palladium-catalyzed coupling with various aryl halides.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes and bioconjugation reagents for target identification and biomarker studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences market.

Basic Information

Product Name	2-Chloro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Al)Aniline
CAS No.	1269233-01-3
Molecular Formula	C12H17BClNO2
Molecular Weight	253.53 g/mol
Synonyms	2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; (2-Chloro-5-aminophenyl)boronic acid pinacol ester; 5-Amino-2-chlorophenylboronic acid pinacol ester; 2-Chloro-5-(pinacolboron)aniline; 2-Chloro-5-aminophenylboronic acid pinacol ester; 2-Chloro-5-boronoaniline pinacol ester; 1269233-01-3; Aniline, 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Tetramethyl-1,3,2-Dioxaborolan-2-Al)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency for reliable synthetic outcomes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed and allowed to reach room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.