Description

2,5-Difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is a high-value, multi-functional boronic ester derivative of aniline, serving as a critical synthetic intermediate. Its core value lies in enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for researchers and manufacturers in pharmaceutical development and agrochemical synthesis who require precise, scalable building blocks for active ingredient discovery and production.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoroaniline and boronate functionalities impart specific biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and bioconjugation reagents for target identification and validation studies.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 2,5-difluoro-3-aminophenyl moiety into complex molecular architectures.
• Library Synthesis for Drug Discovery: A valuable scaffold in combinatorial and parallel synthesis for generating diverse compound libraries for high-throughput screening.

Basic Information

Item	Details
Product Name	2,5-Difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
CAS No.	1269233-00-2
Molecular Formula	C12H16BF2NO2
Molecular Weight	255.07 g/mol
Synonyms	3-Amino-2,6-difluorophenylboronic acid pinacol ester; 2,6-Difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; (3-Amino-2,6-difluorophenyl)boronic acid pinacol ester; 2,5-Difluoro-3-aminophenylboronic acid pinacol ester; Boronic acid, B-(3-amino-2,6-difluorophenyl)-, 1,1-dimethylethyl ester; 1269233-00-2; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,5-difluoroaniline
EINECS	Contact for details

Quality Control

Every batch of our 2,5-Difluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Recommended storage temperature is 2-8°C for prolonged periods.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.