Description

Benzenamine, 5-Chloro-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers in the development and synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and organic electronic materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring a halogenated aniline-boronate moiety for cross-coupling.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the introduction of specific aryl groups is necessary for bioactivity.
• Material Science: Serves as a precursor for organic semiconductors, liquid crystals, and other functional materials that incorporate conjugated aromatic systems.
• Chemical Synthesis: Enables the efficient formation of carbon-carbon bonds in complex molecule construction for academic and industrial research.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or molecular probes for biochemical and diagnostic applications.

Basic Information

Product Name	Benzenamine, 5-Chloro-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1269232-96-3
Molecular Formula	C12H16BClFNO2
Molecular Weight	271.52 g/mol
Synonyms	5-Chloro-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 3-Amino-5-chloro-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-5-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; (3-Amino-5-chloro-2-fluorophenyl)boronic acid pinacol ester; 1269232-96-3; 5-Chloro-2-fluoro-3-(pinacolatoboryl)aniline
EINECS	Contact for details

Quality Control

Our production of Benzenamine, 5-Chloro-2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot is characterized and released with a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support customer audits and can provide material for qualification under cGMP guidelines as required for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for prolonged periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.