Description

Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in heterocyclic chemistry for oncology and CNS targets.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides with improved efficacy and selectivity.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers, OLED materials, and conductive films.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in university and CRO laboratories.
• Scale-up Process Chemistry: Suitable for optimization and pilot-scale production of target molecules for clinical and commercial evaluation.

Basic Information

Product Name	Methyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrrole-3-Carboxylate
CAS No.	1268619-58-4
Molecular Formula	C12H20BNO4
Molecular Weight	253.11 g/mol
Synonyms	1H-Pyrrole-3-carboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylic acid methyl ester; Methyl 5-(pinacolatoboryl)-1H-pyrrole-3-carboxylate; 3-Methoxycarbonyl-1H-pyrrole-5-boronic acid pinacol ester; 1H-Pyrrole-3-carboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester (9CI)
EINECS	Contact for details

Quality Control

Our Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-3-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.