Description

2-(Difluoromethoxy)Isonicotinaldehyde is a specialized fluorinated pyridine derivative, serving as a high-value building block in advanced organic synthesis. Its unique structure, featuring both a difluoromethoxy group and an aldehyde functionality on the pyridine ring, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced organic electronic materials and liquid crystals, where fluorination modifies electronic properties and stability.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-(Difluoromethoxy)Isonicotinaldehyde
CAS No.	1268517-83-4
Molecular Formula	C8H5F2NO2
Molecular Weight	185.13 g/mol
Synonyms	2-(Difluoromethoxy)pyridine-4-carboxaldehyde; 4-Formyl-2-(difluoromethoxy)pyridine; Isonicotinaldehyde, 2-(difluoromethoxy)-; 2-Difluoromethoxyisonicotinaldehyde; Pyridine-4-carboxaldehyde, 2-(difluoromethoxy)-
EINECS	Contact for details

Quality Control

Every batch of 2-(Difluoromethoxy)Isonicotinaldehyde is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture ingress and oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.