Description

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value proposition lies in enabling the efficient synthesis of complex molecules through reliable cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and scalable methods to introduce functionalized pyridine motifs into target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoroethoxy and heterocyclic components for drug discovery and development.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the pyridine-boronate core provides specific biological activity and stability.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for OLEDs and charge-transport materials, due to its electron-deficient pyridine ring.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds, facilitating the construction of complex biaryl and heterobiaryl systems.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes and tags used in diagnostic and imaging applications.
• Ligand and Catalyst Development: Acts as a building block for synthesizing novel chelating ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine
CAS No.	1268467-17-9
Molecular Formula	C13H17BF3NO3
Molecular Weight	303.09 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine; 2-(Trifluoroethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol 2-(2,2,2-Trifluoroethoxy)pyridine-5-boronate; 2-(2,2,2-Trifluoroethoxy)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Borono-2-(2,2,2-trifluoroethoxy)pyridine pinacol ester
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Quality Control

Our 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with exacting standards for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.