Description

5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for constructing complex pyrimidine-based molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing functionalized pyrimidine cores for oncology, antiviral, and CNS therapies.
• Agrochemical Synthesis: Used to create novel pyrimidine-based herbicides, fungicides, and plant growth regulators through palladium-catalyzed coupling reactions.
• Material Science Research: Building block for constructing organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for drug discovery campaigns.
• Academic & Industrial R&D: Fundamental reagent in research laboratories for methodological development in cross-coupling chemistry and heterocyclic compound synthesis.

Basic Information

Product Name	5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
CAS No.	1268467-16-8
Molecular Formula	C11H19BN2O3
Molecular Weight	238.09 g/mol
Synonyms	2-(5-Methoxypyrimidin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-(5-Methoxy-2-pyrimidinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Methoxypyrimidine-2-boronic acid pinacol ester; 2-(5-Methoxypyrimidin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pyrimidine, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methoxy-
EINECS	Contact for details

Quality Control

Our 5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to cGMP principles and adherence to ISO standards ensure a reliable supply of this high-value intermediate for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.