Description

9-Bromo-2,3,4,5-tetrahydro-1,5-benzoxazepine is a high-value brominated heterocyclic building block, specifically a benzoxazepine derivative, essential for advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecular architectures in pharmaceutical and agrochemical research. This compound is primarily needed by R&D chemists and process development scientists working in medicinal chemistry, particularly for the synthesis of novel therapeutic agents targeting central nervous system disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting GPCRs and kinase enzymes.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns due to its reactive bromine handle.
• Cross-Coupling Reactions: Serves as a crucial substrate for palladium-catalyzed reactions such as Suzuki, Negishi, and Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Ligand and Catalyst Development: Utilized in the preparation of novel chiral ligands and organocatalysts.
• Agrochemical Synthesis: Employed in the research and development of new active ingredients for crop protection.
• Material Science: A building block for creating specialized organic molecules with potential electronic or photophysical properties.

Basic Information

Product Name	9-Bromo-2,3,4,5-tetrahydro-1,5-benzoxazepine
CAS No.	1267996-76-8
Molecular Formula	C10H12BrNO
Molecular Weight	242.11 g/mol
Synonyms	9-Bromo-2,3,4,5-tetrahydro-1,5-benzoxazepine; 1,5-Benzoxazepine, 9-bromo-2,3,4,5-tetrahydro-; 9-Bromo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine; 9-Bromotetrahydro-1,5-benzoxazepine; 1267996-76-8; Benzoxazepine, 9-bromo-2,3,4,5-tetrahydro-
EINECS	Contact for details

Quality Control

Our 9-Bromo-2,3,4,5-tetrahydro-1,5-benzoxazepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.