Description

tert-Butyl 4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine core and a versatile boronic ester pinacol group. This compound is specifically designed for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heteroaryl structures. It is an essential building block for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Enables rapid parallel synthesis and structure-activity relationship (SAR) studies via efficient Suzuki-Miyaura cross-coupling to introduce diverse aromatic and heteroaromatic fragments.
• Agrochemical Development: Used in the research and synthesis of novel herbicides, fungicides, and insecticides that require complex heterocyclic architectures.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Facilitates the creation of labeled compounds and molecular probes for biochemical and diagnostic applications.
• Process Chemistry & Scale-up: Suitable for development from milligram to kilogram scale under GMP-like conditions for clinical trial material production.

Basic Information

Product Name	tert-Butyl 4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.	1265484-33-0
Molecular Formula	C19H32BN3O4
Molecular Weight	377.29 g/mol
Synonyms	1-Boc-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine; tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate; 1-(1-Boc-4-piperidyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(1-Boc-piperidin-4-yl)-1H-pyrazole; BOC-Piperidine-Pyrazole-Boronic Acid Pinacol Ester; 1-N-BOC-4-(4-BPin-pyrazol-1-yl)piperidine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with REACH and other global regulatory frameworks, and can provide material manufactured under quality management systems aligned with ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.