Description

4,4,5,5-Tetramethyl-2-(3,5-Dihydro-2H-Thiopyran-4-Yl)-1,3,2-Dioxaborolane is a high-value, heterocyclic boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those containing thiopyran or dihydrothiopyran motifs for therapeutic applications.
• Agrochemical Synthesis: Used in constructing novel active ingredients for crop protection products, leveraging its boronate functionality for molecular diversification.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as polymers for OLEDs or conductive films.
• Chemical Biology Probes: Employed in the creation of bioconjugation reagents and molecular probes that utilize boronate chemistry for sensing or labeling applications.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis.
• Polymer Modification: Facilitates the introduction of functional groups into polymer backbones via post-polymerization cross-coupling reactions.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(3,5-Dihydro-2H-Thiopyran-4-Yl)-1,3,2-Dioxaborolane
CAS No.	1264198-70-0
Molecular Formula	C13H21BO2S
Molecular Weight	252.18 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-thiopyran; 2-(3,5-Dihydro-2H-thiopyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(3,5-dihydro-2H-thiopyran-4-yl)-1,3,2-dioxaborolane; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-thiopyran; Thiopyran-4-ylboronic acid pinacol ester; 3,6-Dihydro-2H-thiopyran-4-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(3,5-Dihydro-2H-Thiopyran-4-Yl)-1,3,2-Dioxaborolane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ¹¹B) and HPLC analysis, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor quality documentation to meet specific regulatory or project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. For long-term storage, consider storing under an inert gas blanket in a freezer (-20°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.