Description

2-Bromo-3-Fluoropyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is critically needed by R&D and process development teams in the pharmaceutical, agrochemical, and advanced materials industries to create novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to synthesize molecular probes for target identification and validation in drug discovery.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	2-Bromo-3-Fluoropyridine-5-Boronic Acid Pinacol Ester
CAS No.	1264130-85-9
Molecular Formula	C11H14BBrFNO2
Molecular Weight	300.95 g/mol
Synonyms	5-Bromo-6-fluoropyridine-3-boronic acid pinacol ester; (5-Bromo-6-fluoropyridin-3-yl)boronic acid pinacol ester; 2-Bromo-3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Bromo-2-fluoropyridine-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-bromo-3-fluoropyridine; Pinacol (5-bromo-6-fluoropyridin-3-yl)boronate
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Fluoropyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Our standard quality commitment includes comprehensive analysis via HPLC, NMR, and MS to verify identity and purity, meeting the stringent requirements for advanced R&D and scale-up. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (argon/nitrogen) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.