Description

1-[tert-Butyl(Dimethyl)Silyl]-5-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-purity, advanced pharmaceutical intermediate and key building block in modern synthetic chemistry. This compound is specifically designed for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is an essential reagent for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and material science, enabling the creation of novel indole-based molecular architectures.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides with specific biological activity.
• Material Science Research: Serves as a precursor for organic electronic materials, such as OLEDs and conductive polymers.
• Academic & R&D Laboratories: A valuable reagent for methodological development in palladium-catalyzed cross-coupling reactions.
• Chemical Library Synthesis: Enables the rapid, parallel synthesis of diverse indole-containing compound libraries for high-throughput screening.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for commercial active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-[tert-Butyl(Dimethyl)Silyl]-5-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	1263987-17-2
Molecular Formula	C21H34BNO2Si
Molecular Weight	371.40 g/mol
Synonyms	5-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[(2-methylpropan-2-yl)dimethylsilyl]indole; 1-[(tert-Butyl)dimethylsilyl]-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; N-tert-Butyldimethylsilyl-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; 1H-Indole, 1-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-Methyl-1-((tert-butyldimethylsilyl))-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; TBS-Protected 5-Methyl-3-Boronopinacol Indole; 3-Boronic acid pinacol ester of 1-TBS-5-methylindole
EINECS	Contact for details

Quality Control

Our 1-[tert-Butyl(Dimethyl)Silyl]-5-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, critical for sensitive cross-coupling reactions. Each lot is analyzed using advanced techniques including HPLC, NMR, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. For long-term storage, consider storing under an inert gas blanket in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.