Description

4-(Boc-Amino)-3,3-Difluoropiperidine is a high-value, protected piperidine derivative featuring both a Boc-protected amine and two fluorine atoms on the ring. This compound is a critical pharmaceutical intermediate and building block in modern organic synthesis, enabling the efficient construction of complex molecules with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Agrochemical Research: Used in the development of novel herbicides and pesticides, where the difluoropiperidine scaffold can impart favorable properties.
• Peptidomimetics & PROTACs: Serves as a constrained, fluorinated scaffold in the design of peptide mimics and proteolysis-targeting chimeras (PROTACs).
• Chemical Biology Probes: Employed in the synthesis of tool compounds for studying enzyme function and biological pathways.
• Material Science: Potential monomer or precursor for specialty polymers and advanced materials requiring fluorinated components.

Basic Information

Product Name	4-(Boc-Amino)-3,3-Difluoropiperidine
CAS No.	1263180-22-8
Molecular Formula	C10H18F2N2O2
Molecular Weight	236.26 g/mol
Synonyms	4-[(tert-Butoxycarbonyl)amino]-3,3-difluoropiperidine; tert-Butyl (3,3-difluoropiperidin-4-yl)carbamate; 3,3-Difluoropiperidin-4-amine, N-Boc-protected; Boc-4-amino-3,3-difluoropiperidine; 4-(Boc-amino)-3,3-difluoropiperidine; 4-(tert-Butoxycarbonylamino)-3,3-difluoropiperidine; 4-(N-Boc-amino)-3,3-difluoropiperidine; 3,3-Difluoro-4-(Boc-amino)piperidine
EINECS	Contact for details

Quality Control

Our 4-(Boc-Amino)-3,3-Difluoropiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.