Description

4-Biphenylboronic Acid Mida Ester is a high-value, protected boronic acid derivative that offers enhanced stability and handling properties compared to its free boronic acid counterpart. This compound is a critical synthetic intermediate in modern organic and medicinal chemistry, particularly valued for its role in cross-coupling reactions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the efficient construction of complex biaryl structures.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing biphenyl or substituted biphenyl motifs.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its stability for multi-step synthesis.
• Material Science: Serves as a precursor in the creation of organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed as a stable handle for bioconjugation and the development of activity-based probes and inhibitors.
• Library Synthesis: Ideal for parallel and combinatorial chemistry approaches in high-throughput screening due to its improved shelf-life and reduced propensity for protodeboronation.
• Catalyst & Ligand Development: Used as a synthetic intermediate for creating novel phosphine or N-heterocyclic carbene ligands containing biphenyl backbones.

Basic Information

Product Name	4-Biphenylboronic Acid Mida Ester
CAS No.	1262967-24-7
Molecular Formula	C15H14BNO4
Molecular Weight	283.09 g/mol
Synonyms	4-(N-Methyliminodiacetic acid)boronate Biphenyl; [1,1'-Biphenyl]-4-boronic acid, N-methyliminodiacetic ester; Biphenyl-4-boronic acid MIDA ester; 4-Biphenylboronic Acid N-Methyliminodiacetic Acid (MIDA) Ester; 4-Biphenyl-MIDA-boronate; (4-Biphenylyl)boronic acid MIDA ester; CAS 1262967-24-7
EINECS	Contact for details

Quality Control

Our 4-Biphenylboronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.