Description

1-(5-Bromo-2-Fluorophenyl)-2,2-Difluoroethanone is a high-purity fluorinated and brominated aromatic ketone building block, essential for advanced organic synthesis. This compound is valued for its unique halogenated structure, which enables precise molecular modifications in the development of complex active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce difluoroacetyl and halogenated aryl motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides where the difluoroacetyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals, where halogen and fluorine atoms tune electronic properties.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the global fine chemical market.

Basic Information

Product Name	1-(5-Bromo-2-Fluorophenyl)-2,2-Difluoroethanone
CAS No.	1262858-97-8
Molecular Formula	C8H4BrF3O
Molecular Weight	253.02 g/mol
Synonyms	5-Bromo-2-fluorobenzoyl difluoride; 2,2-Difluoro-1-(5-bromo-2-fluorophenyl)ethanone; 1-(5-Bromo-2-fluorophenyl)-2,2-difluoroethan-1-one; 5-Bromo-2-fluorophenyl difluoroacetyl ketone; α,α-Difluoro-5-bromo-2-fluorobenzeneacetyl chloride (related precursor); DFBAK (abbrev.); (5-Bromo-2-fluorophenyl)(difluoro)methanone
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-2-Fluorophenyl)-2,2-Difluoroethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.