Description

(E)-1-(2-Chloro-5-Thiazolylmethyl)-3-(Methyl-D3)-2-Nitroguanidine CAS NO 1262776-24-8 is a high-purity, deuterated nitroguanidine derivative, a critical advanced intermediate in modern agrochemical and pharmaceutical research. Its core value lies in its role as a key building block for the synthesis of novel neonicotinoid insecticides and other bioactive compounds, where the deuterium labeling provides significant advantages in metabolic stability studies and analytical method development. This compound is essential for R&D chemists and process development scientists in the agrochemical and life sciences industries who require isotopically labeled precursors for tracer studies, metabolic pathway elucidation, and the development of next-generation crop protection agents.

Application

• Agrochemical Intermediate: A pivotal precursor in the synthesis of novel, high-performance neonicotinoid and other insecticide classes.
• Deuterated Standard for Analytical Chemistry: Used as an internal standard in LC-MS and GC-MS for the accurate quantification of non-labeled pesticide residues and metabolites in environmental and food safety testing.
• Metabolic Studies & Drug Discovery: The deuterium (D3) label facilitates pharmacokinetic and metabolic stability investigations in pharmaceutical and agrochemical research, aiding in the design of compounds with improved profiles.
• Process Chemistry & Route Scouting: Employed in the development and optimization of synthetic pathways for complex nitroguanidine-based active ingredients.
• Isotope Labeling Services: Supplied to custom synthesis and contract research organizations (CROs) specializing in labeled compound production.

Basic Information

Item	Details
Product Name	(E)-1-(2-Chloro-5-Thiazolylmethyl)-3-(Methyl-D3)-2-Nitroguanidine
CAS No.	1262776-24-8
Molecular Formula	C7H6D3ClN6O2S
Molecular Weight	277.71 g/mol
Synonyms	3-(Methyl-d3)-N-nitro-1-[(2-chloro-5-thiazolyl)methyl]guanidine; (E)-N-Nitro-1-[(2-chloro-5-thiazolyl)methyl]-3-(trideuteriomethyl)guanidine; Deuterated Clothianidin Intermediate; Nitroguanidine-d3 Derivative; 1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-3-(methyl-d3)-2-nitroguanidine; (E)-1-[(2-Chloro-5-thiazolyl)methyl]-3-(methyl-d3)-2-nitroguanidine
EINECS	Contact for details

Quality Control

Every batch of (E)-1-(2-Chloro-5-Thiazolylmethyl)-3-(Methyl-D3)-2-Nitroguanidine is manufactured and controlled under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. Certificates of Analysis (COA) detailing specifications such as chemical purity (HPLC), isotopic purity (NMR/MS), and residual solvents (GC) are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, NMR/MS)	≥ 98 atom % D
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.