Description

Methyl n-(tert-Butoxycarbonyl)-3,3,3-Trifluoroalaninate is a high-value, protected amino acid derivative, specifically a trifluoromethylalanine ester with a Boc-protected amine. This compound is a critical synthetic intermediate for the introduction of the metabolically stable trifluoromethyl group into peptides and bioactive molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for the development of novel therapeutics, agrochemicals, and advanced materials. The product offers a reliable route to incorporate fluorine atoms, which can dramatically alter a compound's lipophilicity, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated peptide analogs and active pharmaceutical ingredients (APIs) with enhanced properties.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting various proteases, where the trifluoromethyl group mimics a methyl group with increased stability.
• Agrochemical Synthesis: Intermediate for creating advanced herbicides and pesticides with improved environmental persistence and efficacy.
• Peptidomimetics & Drug Discovery: Essential for constructing non-natural amino acids in peptidomimetic scaffolds for drug discovery programs.
• Material Science Research: Employed in the synthesis of fluorinated polymers and specialty materials with unique surface properties.
• Chemical Biology Probes: Serves as a precursor for labeled compounds and probes used to study biological mechanisms.

Basic Information

Product Name	Methyl n-(tert-Butoxycarbonyl)-3,3,3-Trifluoroalaninate
CAS No.	1262414-99-2
Molecular Formula	C10H16F3NO4
Molecular Weight	271.23 g/mol
Synonyms	Boc-3,3,3-trifluoroalanine methyl ester; (tert-Butoxycarbonyl)-3,3,3-trifluoro-L-alanine methyl ester; Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3,3,3-trifluoropropanoate; N-Boc-3,3,3-trifluoroalanine methyl ester; Boc-Tfm-Ala-OMe; 3,3,3-Trifluoroalanine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Methyl N-Boc-3,3,3-trifluoroalaninate
EINECS	Contact for details

Quality Control

Our Methyl n-(tert-Butoxycarbonyl)-3,3,3-Trifluoroalaninate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high-purity standards required for pharmaceutical and advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.