Description

Methyl 2-Amino-2-(Trifluoromethyl)But-3-Ynoate is a high-value trifluoromethylated building block and chiral synthon. This compound matters for its unique structural features, combining an amino group, a trifluoromethyl group, and an alkyne moiety, enabling diverse derivatization for advanced molecular synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals. Its reactivity profile makes it a critical intermediate in medicinal chemistry and material science projects.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those requiring trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the CF3 group can improve activity and environmental profile.
• Chiral Auxiliary/ Ligand Precursor: Serves as a starting material for the preparation of chiral catalysts, ligands, or auxiliaries used in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, or organic electronic materials that incorporate fluorinated segments.
• Chemical Biology Probes: Utilized to create tagged or labeled molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical intermediate for custom synthesis houses serving the global fine chemical market.

Basic Information

Product Name	Methyl 2-Amino-2-(Trifluoromethyl)But-3-Ynoate
CAS No.	1262414-79-8
Molecular Formula	C7H8F3NO2
Molecular Weight	195.14 g/mol
Synonyms	2-Amino-2-(trifluoromethyl)but-3-ynoic acid methyl ester; Methyl 2-amino-2-trifluoromethylbut-3-ynoate; 2-(Trifluoromethyl)-2-aminobut-3-ynoic Acid Methyl Ester; 3-Butynoic acid, 2-amino-2-(trifluoromethyl)-, methyl ester; Methyl α-amino-α-(trifluoromethyl)propiolate
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-2-(Trifluoromethyl)But-3-Ynoate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and adherence to ISO quality standards ensure reliable supply for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.