Description

2-Chloro-6-(Trifluoromethoxy)Benzaldehyde is a versatile and high-value fluorinated aromatic aldehyde building block. This compound matters for its unique trifluoromethoxy (-OCF₃) and chloro substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, as well as by advanced material scientists developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays (LCDs).
• Specialty Polymer Monomer: Incorporated into polymers to impart specific chemical resistance, thermal stability, or unique optical properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) and as a precursor for other functional groups like acids, alcohols, and amines.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Chloro-6-(Trifluoromethoxy)Benzaldehyde
CAS No.	1261822-56-3
Molecular Formula	C₈H₄ClF₃O₂
Molecular Weight	224.56 g/mol
Synonyms	2-Chloro-6-(trifluoromethoxy)benzaldehyde; 2-Chloro-alpha,alpha,α-trifluoro-o-anisaldehyde; 6-Chloro-2-(trifluoromethoxy)benzaldehyde; Benzaldehyde, 2-chloro-6-(trifluoromethoxy)-; o-Chloro-alpha,alpha,α-trifluoroanisaldehyde; 2-Chloro-6-trifluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(Trifluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production adheres to cGMP standards where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain purity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.