Description

1-Bromo-4-(Difluoromethoxy)Naphthalene is a specialized halogenated naphthalene derivative that serves as a high-value synthetic intermediate. This compound matters for its unique molecular architecture, combining a brominated naphthalene core with a difluoromethoxy substituent, which is critical for modulating the electronic and steric properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and advanced materials sectors for constructing complex organic frameworks, particularly in medicinal chemistry and agrochemical research. CAS No. 1261783-62-3.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in developing novel pesticides and herbicides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, or organic electronic materials.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution to introduce the bromonaphthalene moiety into more complex structures.
• Fluorine Chemistry Studies: A valuable substrate for investigating the effects of fluorine and fluorinated alkoxy groups on aromatic systems in academic and industrial R&D.

Basic Information

Product Name	1-Bromo-4-(Difluoromethoxy)Naphthalene
CAS No.	1261783-62-3
Molecular Formula	C₁₁H₇BrF₂O
Molecular Weight	273.08 g/mol
Synonyms	4-Bromo-1-(difluoromethoxy)naphthalene; 1-(Difluoromethoxy)-4-bromonaphthalene; Naphthalene, 1-bromo-4-(difluoromethoxy)-; 1261783-62-3; 1-Bromo-4-difluoromethoxynaphthalene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Difluoromethoxy)Naphthalene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.