Description

2-Chloro-5-Formylbenzonitrile is a versatile and high-value aromatic nitrile building block characterized by its reactive aldehyde and nitrile functional groups. This compound matters for its critical role in the synthesis of complex organic molecules, particularly in the development of advanced pharmaceutical intermediates and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing heterocyclic compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing benzimidazole, quinazoline, or other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the chloro and formyl groups allow for further functionalization.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands used in catalysis and material science.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and light-emitting materials due to its electron-withdrawing nitrile group.
• Dye and Pigment Intermediate: Functions as a building block for synthesizing specialized dyes and colorants.
• Cross-Coupling Reactions: The chloro substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination.

Basic Information

Product Name	2-Chloro-5-Formylbenzonitrile
CAS No.	1261759-41-4
Molecular Formula	C8H4ClNO
Molecular Weight	165.58 g/mol
Synonyms	5-Formyl-2-chlorobenzonitrile; 2-Chloro-5-cyanobenzaldehyde; 5-Cyano-2-chlorobenzaldehyde; 2-Chloro-5-formylbenzonitrile; Benzonitrile, 2-chloro-5-formyl-; 2-Chloro-5-aldehydrobenzonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Formylbenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP standards where applicable, ensuring reliability for your most critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is easily oxidized (store under inert atmosphere) and is light-sensitive. Keep away from strong oxidizing agents, strong bases, and reducing agents. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.