Description

Benzene, 2-Chloro-1,3-Difluoro-5-Iodo- is a highly functionalized halogenated benzene derivative, serving as a critical building block in advanced organic synthesis. Its unique combination of chlorine, fluorine, and iodine substituents on the aromatic ring makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates requiring halogenated aromatic cores for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the halogen pattern can influence binding to biological targets.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry Building Block: The difluoro motif is valuable for introducing fluorine atoms into target molecules to modulate lipophilicity, bioavailability, and stability.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development and exploring new chemical spaces in heterocyclic and aromatic chemistry.

Basic Information

Product Name	Benzene, 2-Chloro-1,3-Difluoro-5-Iodo-
CAS No.	1261685-21-5
Molecular Formula	C6H2ClF2I
Molecular Weight	274.44 g/mol
Synonyms	2-Chloro-1,3-difluoro-5-iodobenzene; 1-Chloro-2,4-difluoro-6-iodobenzene; 5-Iodo-2-chloro-1,3-difluorobenzene; 2-Chloro-1,3-difluoro-5-iodo-benzene; 2-Chloro-5-iodo-1,3-difluorobenzene; 1,3-Difluoro-2-chloro-5-iodobenzene; 2-Chloro-1,3-difluoro-5-iodo-Benzene (CAS 1261685-21-5)
EINECS	Contact for details

Quality Control

Our Benzene, 2-Chloro-1,3-Difluoro-5-Iodo- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and degradation. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.