Description

4-Bromo-1-(difluoromethoxy)-2-iodobenzene is a high-purity, multi-halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromine, iodine, and a difluoromethoxy group, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals with specific optical or electronic properties.
• Cross-Coupling Reactions: The bromine and iodine substituents provide orthogonal reactivity for sequential Suzuki, Stille, or Sonogashira cross-coupling reactions to build complex biaryl systems.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and fragment-based drug discovery to explore novel chemical space.
• Fluorine Chemistry: The difluoromethoxy moiety is a valuable source of fluorine atoms for introducing fluorinated groups into target molecules, a common strategy to improve drug-like properties.

Basic Information

Product Name	4-Bromo-1-(difluoromethoxy)-2-iodobenzene
CAS No.	1261679-49-5
Molecular Formula	C7H4BrF2IO
Molecular Weight	348.91 g/mol
Synonyms	1-Bromo-4-(difluoromethoxy)-2-iodobenzene; 2-Iodo-4-bromo-1-(difluoromethoxy)benzene; 4-Bromo-2-iodo-1-(difluoromethoxy)benzene; Benzene, 4-bromo-1-(difluoromethoxy)-2-iodo-; 4-Bromo-2-iodophenyl difluoromethyl ether; 1261679-49-5 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(difluoromethoxy)-2-iodobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting customer specifications and industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.