Description

3,6-Difluoro-2-Methoxybenzyl Bromide is a high-value fluorinated benzyl bromide building block, essential for the synthesis of complex organic molecules. Its core value lies in the strategic introduction of fluorine atoms and a reactive bromomethyl group, enabling precise structural modifications to enhance the biological activity and physicochemical properties of target compounds. This intermediate is critically needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro-methoxy motif can improve metabolic stability and bioavailability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a linker or tagging reagent for bioconjugation and the development of chemical probes to study biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs serving the life sciences sector.

Basic Information

Product Name	3,6-Difluoro-2-Methoxybenzyl Bromide
CAS No.	1261645-28-6
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	2-(Bromomethyl)-1,4-difluoro-3-methoxybenzene; 1-(Bromomethyl)-2,5-difluoro-6-methoxybenzene; Benzene, 2-(bromomethyl)-1,4-difluoro-3-methoxy-; 3-Methoxy-2,5-difluorobenzyl bromide; (3,6-Difluoro-2-methoxyphenyl)methyl bromide
EINECS	Contact for details

Quality Control

Our 3,6-Difluoro-2-Methoxybenzyl Bromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature and reactive bromide moiety, it is recommended to store under an inert atmosphere for long-term stability and to minimize potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.