Description

2-(Difluoromethoxy)-1-Fluoro-4-Iodobenzene is a high-purity fluorinated and iodinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both difluoromethoxy and iodo substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, where the difluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science Precursor: Serves as a building block for liquid crystals and organic semiconductors, leveraging its halogenated structure for fine-tuning material properties.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings, enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry: Essential for introducing the difluoromethoxy (OCF2H) moiety, a bioisostere for methoxy or hydroxy groups that can improve a compound's lipophilicity and metabolic profile.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and library development in drug discovery programs.

Basic Information

Product Name	2-(Difluoromethoxy)-1-Fluoro-4-Iodobenzene
CAS No.	1261572-00-2
Molecular Formula	C7H4F3IO
Molecular Weight	295.01 g/mol
Synonyms	1-Fluoro-2-(difluoromethoxy)-4-iodobenzene; 4-Iodo-2-(difluoromethoxy)fluorobenzene; 2-(Difluoromethoxy)-4-iodo-1-fluorobenzene; Benzene, 2-(difluoromethoxy)-1-fluoro-4-iodo-; 1-Fluoro-4-iodo-2-(difluoromethoxy)benzene; 4-Iodo-1-fluoro-2-(difluoromethoxy)benzene
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)-1-Fluoro-4-Iodobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive analytical data, including HPLC, GC, and NMR spectroscopy, to verify identity and purity. Certificates of Analysis (COA) are available for every batch and supplied upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.