Description

3-Iodo-2-Methylphenylacetonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both an iodine substituent and a reactive nitrile group, makes it a critical intermediate for constructing complex molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the synthesis of heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the iodine atom facilitates further functionalization.
• Material Science Research: Acts as a monomer or building block for developing specialty polymers and liquid crystals with unique electronic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings to form carbon-carbon bonds.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems due to its bio-orthogonal reactivity.

Basic Information

Item	Details
Product Name	3-Iodo-2-Methylphenylacetonitrile
CAS No.	1261569-73-6
Molecular Formula	C9H8IN
Molecular Weight	257.07 g/mol
Synonyms	2-(3-Iodo-2-methylphenyl)acetonitrile; (3-Iodo-2-methylphenyl)acetonitrile; 3-Iodo-o-tolylacetonitrile; α-Cyano-3-iodo-2-methyltoluene; 2-Methyl-3-iodobenzyl cyanide; 1261569-73-6; 3-Iodo-2-methylbenzyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Iodo-2-Methylphenylacetonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.