Description

2-Methyl-4-(Trifluoromethyl)Pyrimidine-5-Carbaldehyde is a high-purity, advanced pharmaceutical intermediate characterized by its reactive aldehyde group and trifluoromethyl-substituted pyrimidine core. This compound is a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring enhanced metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of antiviral, anticancer, and central nervous system (CNS) active drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced materials.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up services for clients in life sciences.

Basic Information

Item	Detail
Product Name	2-Methyl-4-(Trifluoromethyl)Pyrimidine-5-Carbaldehyde
CAS No.	1260783-89-8
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	5-Formyl-2-methyl-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)-2-methyl-5-pyrimidinecarboxaldehyde; 2-Methyl-4-trifluoromethylpyrimidine-5-carbaldehyde; 5-Pyrimidinecarboxaldehyde, 2-methyl-4-(trifluoromethyl)-; 2-Methyl-4-(trifluoromethyl)-5-pyrimidinecarbaldehyde
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-4-(Trifluoromethyl)Pyrimidine-5-Carbaldehyde adheres to stringent quality management systems. Every batch is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with each shipment. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.