Description

2-Chloro-1-(5-(Trifluoromethyl)Pyridin-2-Yl)Ethanone is a high-value trifluoromethylpyridine derivative and a versatile chemical building block. Its molecular structure, featuring a reactive α-chloroketone group adjacent to a pyridine ring, makes it a critical intermediate for synthesizing more complex molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients. We supply this intermediate with a focus on consistent purity and reliable global supply chains to support your advanced synthesis projects.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethylpyridine moiety enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel pyridine-based ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of specialty polymers and advanced organic electronic materials due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: An essential building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Chloro-1-(5-(Trifluoromethyl)Pyridin-2-Yl)Ethanone
CAS No.	1260763-79-8
Molecular Formula	C8H5ClF3NO
Molecular Weight	223.58 g/mol
Synonyms	2-Chloro-1-[5-(trifluoromethyl)-2-pyridinyl]ethanone; 2-Chloro-1-(5-trifluoromethylpyridin-2-yl)ethan-1-one; 2-Acetyl-5-(trifluoromethyl)pyridine chloride; 2-Chloro-1-(5-(trifluoromethyl)pyridin-2-yl)ethanone; α-Chloro-2-(5-trifluoromethylpyridyl) ketone; 5-(Trifluoromethyl)-2-pyridyl chloromethyl ketone
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-1-(5-(Trifluoromethyl)Pyridin-2-Yl)Ethanone is produced and tested under a strict quality management system. Our standard grade typically meets a purity specification of ≥97% (by HPLC), ensuring reliability for your synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity confirmation, and impurity profiles. For projects requiring compliance with specific pharmacopeial standards (e.g., ICH guidelines), please contact us to discuss custom synthesis and analytical protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to prevent moisture absorption and decomposition. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.