Description

5-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is a high-purity, advanced pharmaceutical intermediate featuring a unique fused-ring structure with a trifluoromethyl substituent. This compound is valued for its role in modulating the pharmacokinetic and metabolic properties of active pharmaceutical ingredients, making it a critical building block in modern drug discovery. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel therapeutic agents and crop protection solutions.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocyclic structures.

Basic Information

Product Name	5-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline
CAS No.	1260683-15-5
Molecular Formula	C10H10F3N
Molecular Weight	201.19 g/mol
Synonyms	5-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-5-(trifluoromethyl)quinoline; 5-Trifluoromethyl-1,2,3,4-tetrahydroquinoline; 5-CF3-Tetrahydroquinoline; 5-(Trifluoromethyl)THQ; Quinoline, 1,2,3,4-tetrahydro-5-(trifluoromethyl)-; 1260683-15-5
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under an inert atmosphere such as nitrogen, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Typical 98-99%)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.