Description

Benzenebutanoic Acid, 4-(1,1-Dimethylethyl)-α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is a specialized, optically active amino acid derivative featuring a tert-butylphenyl side chain and an Fmoc-protected amine group. This compound is a critical building block in modern organic synthesis, particularly for the solid-phase peptide synthesis (SPPS) of complex, non-natural peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic research laboratories focused on developing novel therapeutic agents and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected unnatural amino acid for the controlled assembly of peptides with enhanced stability, bioavailability, or specific receptor binding properties.
• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates targeting metabolic disorders, neurological conditions, and oncological pathways.
• Peptidomimetic Design: Used to incorporate hydrophobic, bulky side chains into peptide backbones to create molecules that mimic natural peptides but with improved pharmacokinetic profiles.
• Chemical Biology Research: Employed in the synthesis of labeled peptides or peptide-based probes for studying protein-protein interactions and enzyme mechanisms.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other targeted biotherapeutics.
• Material Science: Potential use in the synthesis of specialized polymers and functionalized surfaces for biomedical applications.

Basic Information

Product Name	Benzenebutanoic Acid, 4-(1,1-Dimethylethyl)-α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)-
CAS No.	1260587-14-1
Molecular Formula	C29H31NO4
Molecular Weight	457.56 g/mol
Synonyms	Fmoc-4-tert-butyl-DL-phenylalanine; (αS)-4-(1,1-Dimethylethyl)-α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]benzenebutanoic acid; Fmoc-4-tert-butyl-Phe-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(tert-butyl)-DL-phenylalanine; Fmoc-DL-4-tert-butylphenylalanine; N-Fmoc-4-tert-butyl-DL-phenylalanine; 4-tert-Butyl-DL-phenylalanine, N-Fmoc derivative; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our high-purity amino acid derivatives are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Certificates are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee (for specified enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.