Description

3’,5’-Difluoro-2-Hydroxyacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a phenolic hydroxyl and a ketone group flanked by fluorine atoms, makes it a versatile precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries. It serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where fluorine atoms enhance biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced polymers and organic electronic materials due to its fluorinated aromatic core.
• Chemical Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Academic & Industrial R&D: A valuable reagent for exploring novel organic reactions and synthesizing fluorinated heterocyclic compounds.

Basic Information

Product Name	3’,5’-Difluoro-2-Hydroxyacetophenone
CAS No.	1260403-62-0
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	1-(2-Hydroxy-3,5-difluorophenyl)ethan-1-one; 2'-Hydroxy-3',5'-difluoroacetophenone; 3,5-Difluoro-2-hydroxyacetophenone; 2-Acetyl-3,5-difluorophenol; Ethanone, 1-(2-hydroxy-3,5-difluorophenyl)-; 3',5'-Difluoro-2'-hydroxyacetophenone
EINECS	Contact for details

Quality Control

Our 3’,5’-Difluoro-2-Hydroxyacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.