Description

2-(tert-Butylamino)Sulfonyl-Phenylboronic Acid Pinacol Ester is a sophisticated organoboron building block featuring a unique sulfonamide-protected aniline moiety. This compound is valued for its dual functionality, serving as a protected boronic ester for Suzuki-Miyaura cross-coupling reactions while also offering a masked amine handle for further derivatization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of complex, nitrogen-containing aromatic targets.

Application

• Pharmaceutical Intermediate: A key building block for constructing novel drug candidates, particularly in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides that require specific aryl-amine architectures.
• Material Science Research: Employed in the creation of functional organic materials, such as organic semiconductors or metal-organic frameworks (MOFs), where precise molecular geometry is critical.
• Cross-Coupling Reactions: Serves as a stable, air-tolerant boronic ester partner in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl linkages.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Parallel & Combinatorial Chemistry: An ideal candidate for library synthesis in high-throughput screening due to its orthogonal reactivity.

Basic Information

Product Name	2-(tert-Butylamino)Sulfonyl-Phenylboronic Acid Pinacol Ester
CAS No.	1260231-89-7
Molecular Formula	C₁₆H₂₆BNO₄S
Molecular Weight	339.26 g/mol
Synonyms	2-[(tert-Butylamino)sulfonyl]phenylboronic acid pinacol ester; N-tert-Butyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide; 2-(N-tert-Butylsulfamoyl)phenylboronic acid pinacol ester; B-[2-[(1,1-Dimethylethyl)amino]sulfonyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(tert-Butylsulfamoyl)phenylboronic acid pinacol ester; Pinacol 2-(N-tert-butylsulfamoyl)phenylboronate
EINECS	Contact for details

Quality Control

Every batch of 2-(tert-Butylamino)Sulfonyl-Phenylboronic Acid Pinacol Ester is produced under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.