Description

2-Chloro-4-Methyl-3-Nitropyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable, high-purity intermediate for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Building block for developing organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing novel ligands and catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Chloro-4-Methyl-3-Nitropyridine-5-Boronic Acid Pinacol Ester
CAS No.	1260156-97-5
Molecular Formula	C₁₂H₁₄BClN₂O₄
Molecular Weight	296.51 g/mol
Synonyms	(5-((4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl))-2-chloro-4-methyl-3-nitropyridine; 2-Chloro-4-methyl-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Chloro-3-nitro-4-methylpyridine-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-4-methyl-3-nitropyridine; Pinacol (2-chloro-4-methyl-3-nitropyridin-5-yl)boronate; CAS 1260156-97-5; Boronic acid, B-(2-chloro-4-methyl-3-nitro-5-pyridinyl)-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Methyl-3-Nitropyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our standard grade typically meets a purity specification of ≥95% (by HPLC), with detailed impurity profiling available. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from tests including HPLC, NMR (¹H, ¹³C), and mass spectrometry. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.