Description

6-Chloro-2-Methylpyrimidine-4-Boronic Acid Pinacol Ester is a high-value organoboron building block, specifically a pyrimidine boronic ester derivative. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyrimidine-based drug candidates in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides containing functionalized pyrimidine cores.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and other functional organic compounds.
• Cross-Coupling Reactions: Specifically designed as a coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to form carbon-carbon bonds.
• Chemical Library Development: Employed in parallel and combinatorial synthesis to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	6-Chloro-2-Methylpyrimidine-4-Boronic Acid Pinacol Ester
CAS No.	1260148-41-1
Molecular Formula	C11H16BClN2O2
Molecular Weight	254.52 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(6-chloro-2-methylpyrimidin-4-yl)-1,3,2-dioxaborolane; 6-Chloro-2-methylpyrimidine-4-boronic acid pinacol ester; 2-(6-Chloro-2-methyl-4-pyrimidinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 6-Chloro-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; Pinacol 6-chloro-2-methylpyrimidine-4-boronate
EINECS	Contact for details

Quality Control

Our 6-Chloro-2-Methylpyrimidine-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.