Description

1-(Oxetan-3-Yl)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is a high-value pharmaceutical intermediate and chemical building block featuring both an oxetane ring and a boronic ester pinacol group. This unique bifunctional structure makes it a critical reagent for the synthesis of complex molecules, particularly in medicinal chemistry and drug discovery. It is primarily sought after by research institutions and pharmaceutical companies for the development of novel therapeutics, including kinase inhibitors and targeted covalent inhibitors. The compound's design facilitates advanced cross-coupling reactions and serves as a key precursor in the creation of bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitor candidates.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop novel drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety serves as a crucial coupling partner for constructing biaryl and heterobiaryl structures.
• Proteolysis Targeting Chimera (PROTAC) Development: Utilized as a linker component or warhead ligand in the design of targeted protein degraders.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying enzyme function and biological pathways.
• Material Science Research: Potential precursor for advanced organic electronic materials and polymers.

Basic Information

Product Name	1-(Oxetan-3-Yl)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea
CAS No.	1260088-68-3
Molecular Formula	C16H23BN2O4
Molecular Weight	318.18 g/mol
Synonyms	1-(Oxetan-3-yl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(oxetan-3-yl)aniline-1-carboxamide; Urea, N-(oxetan-3-yl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 1260088-68-3; 3-Oxetanyl-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; B-[4-[[(3-Oxetanyl)amino]carbonyl]amino]phenyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(Oxetan-3-Yl)-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Urea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and easily oxidized nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.